Borne's Scientific Collaborative
Borne has established a scientific collaboration with preterm birth experts from around the world. They agree that the answers to the questions that continue to confound scientists and medics are likely to lie at the seams between different areas of scientific focus and specialisation.
Together, they can advance our understanding of term and dysfunctional labour and accelerate the translation of discoveries into new treatments to delay preterm labour and improve outcome for babies.
The focus of the Collaborative is to systematically study the biological interactions across different cells and tissues to advance our understanding of normal and dysfunctional labour and identify new interventions to delay or prevent preterm labour.
Preterm labour is a complex syndrome. We need to understand the nuanced phenotypes and a woman’s individual risk factors if we are to make progress. This cannot be achieved by researchers working in isolation. This is where interaction with a collaborative and a shared bioresource has the power to be transformative.”
Prof Rachel Tribe, KCL
The invaluable resource that will power this collaboration is the clinical centre of excellence that can provide carefully phenotyped samples from women when they are about to go into labour, and the analysis of the invaluable data generated with these samples by bioinformaticians (the pattern-seekers) and scientists (the hypothesis generators) – together.
Borne's Uterine Mapping Project (BUMP)
Clinical Centre of Excellence
A clinical centre will drive the recruitment of pregnant women to join the BUMP initiative and contribute a variety of maternal tissue when they deliver their babies. These women’s clinical phenotypic profiles will be carefully recorded, and the samples collected and processed in accordance with protocols and techniques specified by this collaboration of scientific experts.
As the link between clinician and patient, Borne’s research midwives are central to this project. They will not only recruit a diverse cohort of pregnant women, but also augment capacity at the frontline, ensuring the best care throughout pregnancy and childbirth.
We intend to harness cutting-edge technologies and artificial intelligence to extract a comprehensive array of scientific data from these samples, and engage with the Borne Collaborative and their scientific teams across different specialisations to better understand the complexity of the integrated biological processes that enable pregnancy and birth.
The cross-tissue analysis facilitated by the bioresource will enable scientists to validate their work as part of the ‘bigger picture’. This will spark breakthroughs in understanding by bridging the gap between different areas of specialisation.
In addition, this precious bioresource of tissue from a diverse and well- documented cohort of women should attract more researchers to access and contribute to the project with their hypotheses and analyses.
The project will create an invaluable open-source map representing the collective knowledge of this world-class group of scientific experts. Importantly, it will extend the scope and context of their work to accelerate the advancement of knowledge and discovery in ways that are simply not possible without collaboration.
It is a new way of approaching discovery science to crack the code on premature birth.
Please support our work
This year, Borne is taking part in The Big Give’s Christmas Challenge, the UK’s largest match funding campaign. Between 1-8 December 2020, all online donations to our Christmas Campaign will be doubled from a matching pot.
Help us secure this pledged funding and your donation will go twice as far towards creating a world where no baby is born too soon. Register your pledge here.
Become a Friend of Borne by making a regular gift. No gift is too small.
Friends of Borne come together to achieve remarkable things. This year, we are working to fund a midwife who is there for women and babies at what can be the most spectacular, terrifying, or heartbreaking time of their lives.